Mouse testicular macrophages can independently produce testosterone and are regulated by Cebpb
This research establishes that TM possess the autonomous capacity to synthesize and secrete testosterone, contributing significantly to testicular testosterone levels. The transcription factor Cebpb plays a crucial role in this process by regulating the expression of key genes involved in testosterone synthesis.
Authors
- Ya Luo (ORCID: https://orcid.org/0000-0001-8299-7948)
- Zhixiang Gao (ORCID: https://orcid.org/0000-0002-5311-4699)
- Fengmei Cui
- Xingyu Lu
- Chen Qiu (ORCID: https://orcid.org/0000-0003-4294-7537)
- Xiaolong Liu (ORCID: https://orcid.org/0009-0004-5457-885X)
- Nengliang Duan (ORCID: https://orcid.org/0000-0002-1161-1996)
- Yuanshuai Ran
- Huapei Wang
- Boxin Xue (ORCID: https://orcid.org/0009-0009-2144-6769)
Institutions
- Soochow University (CN)
- Second Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Biological Research
- Published
- 2024-09-09
- DOI
- https://doi.org/10.1186/s40659-024-00544-8
- Citations
- 5
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 1.20
Funders
- Government of Jiangsu Province
- China National Nuclear Corporation