Synthetic redesign of Escherichia coli W for faster metabolism of sugarcane molasses
Despite limitations in sucrose metabolism, the redesigned E. coli W strain, adept at utilizing sugarcane molasses, is a valuable asset for industrial fermentation. Its synthetic csc operon enhances sucrose consumption, while mitigating CCR improves glucose-fructose co-utilization. These enhancements, coupled with repression of gapA, aim to efficiently convert sugarcane molasses into 3-HP, addressing limitations in sucrose and fructose metabolism for industrial applications.
Authors
- Jina Yang (ORCID: https://orcid.org/0000-0001-5035-3283)
- Sang Woo Seo (ORCID: https://orcid.org/0000-0002-7434-7053)
- Gi Yeon Kim
- Yong Hee Han (ORCID: https://orcid.org/0000-0002-2963-6921)
Institutions
- Chonnam National University (KR)
- Seoul National University (KR)
- National University (SD)
- Jeju National University (KR)
Publication Details
- Journal
- Microbial Cell Factories
- Published
- 2024-09-09
- DOI
- https://doi.org/10.1186/s12934-024-02520-z
- Citations
- 9
- Primary Topic
- Microbial Metabolic Engineering and Bioproduction
- Type
- article
- Field-Weighted Citation Impact
- 2.10
Funders
- National Research Foundation
- Ministry of Oceans and Fisheries
- National Research Foundation of Korea
- Korea Institute of Marine Science and Technology promotion
- Ministry of Science and ICT, South Korea