Molecular xenomonitoring as an indicator of microfilaraemia prevalence for lymphatic filariasis in Samoa in 2019
Findings from this study demonstrate that MX can be a sensitive surveillance method for identifying residual infection in low Mf prevalence settings. MX identified more locations with signals of transmission than Mf-testing. Strong correlation between estimated PCR-positive mosquitoes in the primary vector species and Mf in humans at small spatial scales demonstrates the utility of MX as an indicator for LF prevalence in Samoa and similar settings. Further investigation is needed to develop MX guidelines to strengthen the ability of MX to inform operational decisions.
Authors
- Take Naseri
- Patricia M. Graves (ORCID: https://orcid.org/0000-0002-5215-3901)
- Brady McPherson
- Helen J. Mayfield (ORCID: https://orcid.org/0000-0003-3462-4324)
- Lisa Rigby (ORCID: https://orcid.org/0000-0002-2034-2396)
- Colleen L. Lau (ORCID: https://orcid.org/0000-0001-8288-4169)
- Nils Pilotte (ORCID: https://orcid.org/0000-0002-8447-7425)
- Angus McLure (ORCID: https://orcid.org/0000-0003-2890-2703)
- Robert E. Thomsen
- Sarah Sheridan (ORCID: https://orcid.org/0000-0002-8451-3027)
- Steven A. Williams (ORCID: https://orcid.org/0000-0002-4881-7496)
- Thérèse Kearns (ORCID: https://orcid.org/0000-0003-0862-7572)
- Shannon M. Hedtke (ORCID: https://orcid.org/0000-0002-7499-7662)
- Maddison Howlett
Institutions
- Australian National University (AU)
- The University of Queensland (AU)
- La Trobe University (AU)
- Smith College (US)
- National University of Samoa (WS)
- Charles Darwin University (AU)
- Department of Defence (AU)
- Australian Defence Force Academy (AU)
- National Centre for Immunisation Research & Surveillance (AU)
- Ministry of Health (JM)
- Quinnipiac University (US)
- James Cook University (AU)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2024-09-09
- DOI
- https://doi.org/10.1186/s13071-024-06463-7
- Citations
- 8
- Primary Topic
- Parasitic Diseases Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.11
Funders
- United States Agency for International Development
- Bill and Melinda Gates Foundation
- Medical Research Council
- National Health and Medical Research Council