Metformin Improves Glycemic Control and Postprandial Metabolism and Enhances Postprandial Glucagon-Like Peptide 1 Secretion in Patients With Type 2 Diabetes and Heart Failure: A Randomized, Double-Blind, Placebo-Controlled Trial
This randomized trial tested the effect of metformin on glycemic control and cardiac function in patients with heart failure (HF) and type 2 diabetes while evaluating intestinal effects on selected gut microbiome products reflected by trimethylamine-N-oxide (TMAO) and gut-derived incretins. Metformin treatment improved glycemic control and postprandial metabolism and enhanced postprandial glucagon-like peptide 1 (GLP-1) secretion but did not influence cardiac function or the TMAO levels. Metabolic effects of metformin in HF may be mediated by an improvement in intestinal endocrine function and enhanced secretion of the gut-derived incretin GLP-1.
Authors
- Hana Kahleová (ORCID: https://orcid.org/0000-0003-0491-3993)
- Martin Haluzı́k (ORCID: https://orcid.org/0000-0002-0201-6888)
- Barry A. Borlaug (ORCID: https://orcid.org/0000-0001-9375-0596)
- Tomáš Čajka (ORCID: https://orcid.org/0000-0002-9728-3355)
- Martin Hill (ORCID: https://orcid.org/0000-0002-1705-0835)
- Ondřej Kuda (ORCID: https://orcid.org/0000-0001-7034-4536)
- Jiří Veleba
- KATERINA VELEBOVA
- Lenka Thieme (ORCID: https://orcid.org/0000-0002-3845-7490)
- Vojtěch Melenovský (ORCID: https://orcid.org/0000-0001-8921-7078)
- Eva Hošková (ORCID: https://orcid.org/0000-0002-5744-0598)
- Markéta Segeťová (ORCID: https://orcid.org/0009-0008-1555-562X)
- Ján Kopecký (ORCID: https://orcid.org/0000-0001-8072-2035)
- Jan Beneš (ORCID: https://orcid.org/0000-0002-8304-5612)
- Terezie Pelikánová (ORCID: https://orcid.org/0000-0001-5318-5414)
Institutions
- Physicians Committee for Responsible Medicine (US)
- Czech Academy of Sciences (CZ)
- Mayo Clinic in Arizona (US)
- Institute of Clinical and Experimental Medicine (CZ)
- Institute of Endocrinology (CZ)
- Czech Academy of Sciences, Institute of Physiology (CZ)
Publication Details
- Journal
- Clinical Diabetes
- Published
- 2024-09-09
- DOI
- https://doi.org/10.2337/cd24-0003
- Citations
- 4
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 1.43
Funders
- European Commission