Exposure to angiotensin-converting enzyme inhibitors that cross the blood–brain barrier and the risk of dementia among people with HIV
An artificial intelligence-based literature mining system (AGATHA) was utilized to uncover a medication with potential to be repurposed. AGATHA demonstrated that BBB ACEi as a target for decreasing dementia among PWH. Additionally, we conducted a retrospective study demonstrating a decrease in incident dementia among PWH exposed to BBB ACEi. Future research is needed to explore further and understand the relationship of dementia among PWH exposed to ACEi.
Authors
- Tammy H. Cummings (ORCID: https://orcid.org/0000-0001-7978-7157)
- Michael Shtutman (ORCID: https://orcid.org/0000-0002-2458-3226)
- Joseph Magagnoli (ORCID: https://orcid.org/0000-0002-8568-0097)
- Michael D. Wyatt (ORCID: https://orcid.org/0000-0003-1815-9565)
- Ilya Safro (ORCID: https://orcid.org/0000-0001-6284-7408)
- Aliaksandra Sikirzhytskaya (ORCID: https://orcid.org/0009-0009-5458-9424)
- S. Scott Sutton (ORCID: https://orcid.org/0000-0002-3889-6178)
- Ilya Tyagin (ORCID: https://orcid.org/0000-0002-0249-1072)
Institutions
- University of South Carolina (US)
- Dorn Research Institute (US)
- University of Delaware (US)
Publication Details
- Journal
- AIDS
- Published
- 2024-09-09
- DOI
- https://doi.org/10.1097/qad.0000000000004009
- Primary Topic
- HIV-related health complications and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Veterans Affairs