Evaluation of the Fill-it-up-design to use historical control data in randomized clinical trials with two arm parallel group design
The two-stage Fill-it-up-design represents a frequentist method for including historical control data for various study designs. As the maximum sample size of the design is larger, a robust prior belief is essential for its use. The design should therefore be seen as a way out in exceptional situations where a hybrid design is considered necessary.
Authors
- Martin Posch (ORCID: https://orcid.org/0000-0001-8499-8573)
- Ralf-Dieter Hilgers
- Stephanie Wied (ORCID: https://orcid.org/0000-0003-0616-6610)
Institutions
- Statistics Austria (AT)
- Medical University of Vienna (AT)
- RWTH Aachen University (DE)
Publication Details
- Journal
- BMC Medical Research Methodology
- Published
- 2024-09-09
- DOI
- https://doi.org/10.1186/s12874-024-02306-2
- Citations
- 3
- Primary Topic
- Statistical Methods in Clinical Trials
- Type
- article
- Field-Weighted Citation Impact
- 2.13
Funders
- European Commission
- RWTH Aachen University
- Seventh Framework Programme
- Horizon 2020