Tumour Marker Expression in Head and Neck Malignancies to Identify Potential Targets for Intraoperative Molecular Near-Infrared Imaging
This study highlights integrin αvβ6 and EGFR as viable FLI targets in OSCC and LSCC, especially integrin αvβ6 for tumour margin delineation. In PTC, despite lower expressions, the significant overexpression of VEGF-α, c-MET, and EGFR suggests their potential as FLI targets. Our findings support the development of tumour-targeted FLI tracers to improve surgical precision in HNC.
Authors
- Lisanne K. A. Neijenhuis (ORCID: https://orcid.org/0000-0003-2972-9172)
- Cornelis Verhoef (ORCID: https://orcid.org/0000-0001-9980-8613)
- Tessa M. van Ginhoven (ORCID: https://orcid.org/0000-0002-9365-4892)
- Lorraine J. Lauwerends (ORCID: https://orcid.org/0000-0001-9704-7806)
- Sjors A. Koppes (ORCID: https://orcid.org/0000-0002-8833-531X)
- Alexander L. Vahrmeijer (ORCID: https://orcid.org/0000-0001-9370-0011)
- Bo E. Zweedijk
- Hidde A. Galema (ORCID: https://orcid.org/0000-0002-7777-0754)
- Denise E. Hilling (ORCID: https://orcid.org/0000-0002-5875-6164)
- Peter J.K. Kuppen (ORCID: https://orcid.org/0000-0002-0294-3251)
- Shadhvi S. Bhairosingh
- N. Geeske Dekker-Ensink
- Robert J. Baatenburg de Jong (ORCID: https://orcid.org/0000-0001-7236-264X)
- Stijn Keereweer (ORCID: https://orcid.org/0000-0003-4665-6868)
- Senada Koljenović (ORCID: https://orcid.org/0000-0002-5185-3455)
Institutions
- Leiden University (NL)
- Erasmus MC (NL)
- Antwerp University Hospital (BE)
- Centre for Human Drug Research (NL)
- Erasmus MC Cancer Institute (NL)
- Erasmus University Rotterdam (NL)
- Stanford University (US)
Publication Details
- Journal
- Molecular Diagnosis & Therapy
- Published
- 2024-09-09
- DOI
- https://doi.org/10.1007/s40291-024-00742-w
- Citations
- 4
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.74
Funders
- Erasmus Medisch Centrum