Evaluating metagenomics and targeted approaches for diagnosis and surveillance of viruses
Metagenomics has the potential to become standard-of-care in diagnostics and is a powerful tool for the discovery of emerging pathogens. Untargeted Illumina and ONT metagenomics and capture with the Twist CVRP have different advantages with respect to sensitivity, specificity, turnaround time and cost, and the optimal method will depend on the clinical context.
Authors
- Oscar Enrique Torres Montaguth (ORCID: https://orcid.org/0000-0003-4234-6037)
- Cristina Venturini (ORCID: https://orcid.org/0000-0002-4769-7912)
- Luz Marina Martin Bernal
- Sergi Castellano (ORCID: https://orcid.org/0000-0002-5819-4210)
- Sarah Buddle (ORCID: https://orcid.org/0000-0002-4738-9469)
- Nathaniel Storey (ORCID: https://orcid.org/0000-0001-5942-4674)
- Julianne R. Brown (ORCID: https://orcid.org/0000-0002-4681-9586)
- Laura Atkinson (ORCID: https://orcid.org/0000-0001-6724-9589)
- Sunando Roy (ORCID: https://orcid.org/0000-0001-5968-9111)
- Heli Harvala (ORCID: https://orcid.org/0000-0001-9154-4190)
- Sofia Morfopoulou (ORCID: https://orcid.org/0000-0001-8181-4548)
- Tanya Golubchik (ORCID: https://orcid.org/0000-0003-2765-9828)
- Charles M. Miller (ORCID: https://orcid.org/0000-0001-6413-7389)
- Peter Simmonds (ORCID: https://orcid.org/0000-0002-7964-4700)
- Judith Breuer (ORCID: https://orcid.org/0000-0001-8246-0534)
- Timothy Best
- Leysa Forrest
- Naomi Akinsuyi
- Tony Brooks
- Sian Goldsworthy
- Rachel Williams (ORCID: https://orcid.org/0000-0001-9069-6416)
Institutions
- The University of Sydney (AU)
- NHS Blood and Transplant (GB)
- Great Ormond Street Hospital (GB)
- Great Ormond Street Hospital for Children NHS Foundation Trust (GB)
- University of Oxford (GB)
- Institute of Infection and Immunity (CA)
- University College London (GB)
- Imperial College London (GB)
Publication Details
- Journal
- Genome Medicine
- Published
- 2024-09-09
- DOI
- https://doi.org/10.1186/s13073-024-01380-x
- Citations
- 40
- Primary Topic
- Bacteriophages and microbial interactions
- Type
- article
- Field-Weighted Citation Impact
- 18.36