Neural Network Formation and Functional Regeneration Using Human Pluripotent Stem Cell-derived Neurons

Human pluripotent stem cells, including embryonic stem cells and induced pluripotent stem cells, are emerging as new scientific fields for understanding the pathology of human diseases, regenerative medicine, and drug discovery. In recent years, advanced technologies for cell culture and neuronal differentiation of human cells have provided stable and reproducible methods, contributing to the development of new cross-disciplinary scientific trends alongside various research technologies. Here, we introduce our recent research on brain region-specific neuronal differentiation and brain organoid induction from human pluripotent stem cells, as well as their application for disease modeling and regenerative medicine. Furthermore, we discuss the future direction and application of human pluripotent stem cell technology in advancing scientific discovery.