Model-agnostic neural mean field with a data-driven transfer function

As one of the most complex systems known to science, modeling brain behavior and function is both fascinating and extremely difficult. Empirical data is increasingly available from <i>ex vivo</i> human brain organoids and surgical samples, as well as <i>in vivo</i> animal models, so the problem of modeling the behavior of large-scale neuronal systems is more relevant than ever. The statistical physics concept of a mean-field model offers a tractable way to bridge the gap between single-neuron and population-level descriptions of neuronal activity, by modeling the behavior of a single representative neuron and extending this to the population. However, existing neural mean-field methods typically either take the limit of small interaction sizes, or are applicable only to the specific neuron models for which they were derived. This paper derives a mean-field model by fitting a transfer function called Refractory SoftPlus, which is simple yet applicable to a broad variety of neuron types. The transfer function is fitted numerically to simulated spike time data, and is entirely agnostic to the underlying neuronal dynamics. The resulting mean-field model predicts the response of a network of randomly connected neurons to a time-varying external stimulus with a high degree of accuracy. Furthermore, it enables an accurate approximate bifurcation analysis as a function of the level of recurrent input. This model does not assume large presynaptic rates or small postsynaptic potential size, allowing mean-field models to be developed even for populations with large interaction terms.