A TCM formula assists temozolomide in anti-melanoma therapy by suppressing the STAT3 signaling pathway
Synergistic anti-melanoma effects of SLE/TMZ have been observed in animal and cellular models. One of the mechanisms of SLE/TMZ that underlies its anti-melanoma actions is inhibition of the STAT3 pathway. This work offers pre-clinical pharmacological backing for the advancement of SLE as a therapeutic agent to be used in conjunction with TMZ for the treatment of melanoma.
Authors
- Kaihua Long
- Tingting Huang (ORCID: https://orcid.org/0000-0001-5001-0782)
- Li Ye (ORCID: https://orcid.org/0000-0001-7688-4867)
- Lu Wang (ORCID: https://orcid.org/0000-0001-6336-5806)
- Hong Zhang (ORCID: https://orcid.org/0000-0002-6191-0046)
- Yuxi Liu (ORCID: https://orcid.org/0000-0002-9871-6650)
- Yuan Wang (ORCID: https://orcid.org/0000-0003-0424-8583)
- Yang Liu (ORCID: https://orcid.org/0000-0001-5586-623X)
Institutions
- Northwest University (CN)
- Affiliated Hospital of Shaanxi University of Chinese Medicine (CN)
- Shaanxi Provincial Hospital of Traditional Chinese Medicine (CN)
- Shaanxi University of Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2024-09-08
- DOI
- https://doi.org/10.1016/j.jep.2024.118810
- Citations
- 2
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- Key Research and Development Projects of Shaanxi Province