Microglial morphological/inflammatory phenotypes and endocannabinoid signaling in a preclinical model of periodontitis and depression
The combined effects on microglial morphology and inflammatory phenotype, the EC signaling, and proteins related to synaptic plasticity in P + CMS + animals may represent relevant mechanisms explaining the association between periodontitis and depression. These findings highlight potential therapeutic targets that warrant further investigation.
Authors
- Marina Muñoz‐López (ORCID: https://orcid.org/0000-0003-4817-9639)
- Nagore Ambrosio (ORCID: https://orcid.org/0000-0001-9837-5393)
- Borja García‐Bueno (ORCID: https://orcid.org/0000-0001-7320-1530)
- Leire Virto (ORCID: https://orcid.org/0000-0002-3376-5232)
- Javier Robledo‐Montaña (ORCID: https://orcid.org/0000-0002-6975-3452)
- Mariano Sanz (ORCID: https://orcid.org/0000-0002-6293-5755)
- David Herrera (ORCID: https://orcid.org/0000-0002-5554-2777)
- María Martínez (ORCID: https://orcid.org/0000-0002-6308-4243)
- David Martín‐Hernández (ORCID: https://orcid.org/0000-0003-0195-2604)
- Juan Carlos Leza (ORCID: https://orcid.org/0000-0002-9901-0094)
- Elena Figuero (ORCID: https://orcid.org/0000-0002-3129-1416)
- Eduardo Montero (ORCID: https://orcid.org/0000-0003-2525-8529)
- María José Marín (ORCID: https://orcid.org/0000-0003-0206-4756)
- César Díaz-García (ORCID: https://orcid.org/0009-0006-2019-8570)
Institutions
- Universidad Complutense de Madrid (ES)
- Instituto Cajal (ES)
- Instituto de Salud Carlos III (ES)
- Research Institute Hospital 12 de Octubre (ES)
- Centro de Investigación Biomédica en Red de Salud Mental (ES)
- Medical Research Network (US)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2024-09-08
- DOI
- https://doi.org/10.1186/s12974-024-03213-5
- Citations
- 11
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 4.93
Funders
- Centro de Investigación Biomédica en Red de Salud Mental
- Instituto de Salud Carlos III