Mesenchymal stem cells improve depressive disorder via inhibiting the inflammatory polarization of microglia
Depressive disorder (DD) ranks among the most prevalent, burdensome, and costly psychiatric conditions globally. It manifests through a range of emotional, cognitive, somatic, and behavioral symptoms. Mesenchymal Stem Cells (MSCs) have garnered significant attention due to their therapeutic potential via immunomodulation in neurological disorders. Our research indicates that MSCs treatment demonstrates a notable effect on a Chronic Unpredictable Mild Stress (CUMS)-induced DD model in mice, surpassing even Fluoxetine in its antidepressant efficacy. MSCs mitigate DD by inhibiting central nervous system inflammation and facilitating the conversion of microglial cells into an Arg1<sup>high</sup> anti-inflammatory state. The MSCs-derived TGF-β1 is crucial for this Arg1<sup>high</sup> microglial cell transformation in DD treatment.
Authors
- Xuerui Yu
- Shaochang Jia
- Qianqian Wang
- Min Hong (ORCID: https://orcid.org/0000-0002-2086-8937)
- Jie Zheng (ORCID: https://orcid.org/0000-0001-7601-9152)
- Yao Lü (ORCID: https://orcid.org/0000-0002-3380-7762)
- Yifan Xu (ORCID: https://orcid.org/0009-0007-1024-0621)
- Sijie Zhu (ORCID: https://orcid.org/0000-0002-0827-3156)
- Yuheng Zhang (ORCID: https://orcid.org/0000-0002-6785-0443)
- Longwei Jiang
Institutions
- Nanjing University of Chinese Medicine (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Nanjing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Journal of Psychiatric Research
- Published
- 2024-09-08
- DOI
- https://doi.org/10.1016/j.jpsychires.2024.09.005
- Citations
- 7
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.73
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation