Antihypertensive effect of a nanoemulsion of <i>baccharis dracunculifolia</i> leaves extract in sodium-dependent hypertensive rats
<i>Baccharis dracunculifolia</i> (DC) is an important botanical source of Brazilian green propolis and have many compounds with potential antihypertensive activity. However, little is known about the specific antihypertensive properties of DC, or the mechanisms involved. Here we aimed to chemically characterise an ethanolic DC extract (eDC), test its antihypertensive properties and the involvement of neurogenic mechanisms using an animal model of salt-dependent hypertension. The chemical analysis of the eDC revealed the presence of many antihypertensive compounds. Administering the eDC in a nanoemulsion formulation (25 to 50 mg/kg) effectively normalised blood pressure in hypertensive rats. The result also suggested that neurogenic mechanisms are involved in the antihypertensive action of eDC. The treatment with <i>p</i>-coumaric acid (0.32 to 3 mg/kg), a polyphenol abundant in the eDC, produced no significant antihypertensive effect. The findings indicate that the eDC has antihypertensive properties, and that these effects may be mediated through neurogenic pressor mechanisms.
Authors
- Vagner Roberto Antunes (ORCID: https://orcid.org/0000-0002-6949-012X)
- Flávio Eduardo Dias Araújo Freitas
- Sandra Aparecida Lima de Moura (ORCID: https://orcid.org/0000-0002-3406-0437)
- Orlando David Henrique dos Santos (ORCID: https://orcid.org/0000-0002-8904-6990)
- Geraldo Célio Brandão (ORCID: https://orcid.org/0000-0002-7330-051X)
- Marcos Adriano Carlos Batista (ORCID: https://orcid.org/0000-0002-4725-0790)
- Leonardo Máximo Cardoso (ORCID: https://orcid.org/0000-0001-9821-0484)
- Markus Kohlhoff (ORCID: https://orcid.org/0000-0001-5982-6083)
- Carla S. Ceron (ORCID: https://orcid.org/0000-0001-8882-5792)
- Daiane Cristina de Assis Braga (ORCID: https://orcid.org/0000-0001-8125-8035)
- Gustavo Henrique Bianco de Souza (ORCID: https://orcid.org/0000-0002-1548-3274)
- Jaqueline Aparecida de Souza (ORCID: https://orcid.org/0000-0002-8157-4692)
Institutions
- Universidade Federal de Ouro Preto (BR)
- Universidade Federal de Minas Gerais (BR)
- Universidade de São Paulo (BR)
- Faculdades Oswaldo Cruz (BR)
- Institute of Biophysics (RU)
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- Natural Product Research
- Published
- 2024-09-08
- DOI
- https://doi.org/10.1080/14786419.2024.2397724
- Citations
- 3
- Primary Topic
- Natural Antidiabetic Agents Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.07
Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais
- Universidade Federal de Ouro Preto