A case presentation of widespread macular amyloidosis associated with dual hepatitis B and hepatitis C infection

Macular amyloidosis is a variant of primary localized cutaneous amyloidosis in which amyloid protein is believed to be derived from keratinocytes. The care of this variant generally focuses on addressing the associated symptoms without the need to assess for underlying disease. However, an increasing number of cases of primary localized cutaneous amyloidosis have been reported in association with systemic diseases, particularly autoimmune diseases. A few cases of biphasic primary localized cutaneous amyloidosis have been reported in association with chronic hepatitis C infection. Herein, we report an unusual patient, a 38-year-old man with widespread macular amyloidosis concurrently presenting with dual hepatitis B virus and hepatitis C virus infections. Collecting similar cases can further validate this uncommon association.