Studies on absorption mechanism and pharmacokinetic properties of albendazole-bile acid conjugate: In vivo and in vitro
The transmembrane transport mechanism of ABCs involves a combination of ASBT-mediated active transport and passive diffusion. Moreover, the incorporation of BAs successfully reverses the efflux of ABZ by efflux proteins. Among the synthesized conjugates, ABC-C4 demonstrated superior dissolution behavior both in vitro and in vivo.
Authors
- Chunhui Hu (ORCID: https://orcid.org/0000-0002-8314-547X)
- Kaili Nie (ORCID: https://orcid.org/0000-0002-0613-9850)
- Zhimei Guo (ORCID: https://orcid.org/0000-0002-7242-1731)
- Jingshuai Liu
- Shizhen Tang
Institutions
- Qinghai University (CN)
- Beijing University of Chemical Technology (CN)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2024-09-08
- DOI
- https://doi.org/10.1016/j.biopha.2024.117400
- Citations
- 8
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.26
Funders
- Department of Science and Technology, Ministry of Science and Technology, India
- Qinghai Provincial Department of Science and Technology