Development and Evaluation of Thrombin-Loaded Gelatin Hemostatic Sheets for Spinal Surgery Applications
A thrombin-loaded hemostatic sheet produced from 4% gelatin solution with a short heating time for crosslinking demonstrated well-balanced material properties, such as shape retention, biodegradability, and wet expansion rate, which resulted in effective hemostasis in in vivo models. These advances may contribute to surgical hemostatic applications.
Authors
- Atsuyuki Kawabata (ORCID: https://orcid.org/0000-0001-8057-7237)
- Toshitaka Yoshii (ORCID: https://orcid.org/0000-0003-3511-9020)
- Makoto Ogino
- Satoru Egawa (ORCID: https://orcid.org/0000-0001-9367-3906)
Institutions
- Tokyo Medical and Dental University (JP)
- Astellas Pharma (Japan) (JP)
Publication Details
- Journal
- Spine Surgery and Related Research
- Published
- 2024-09-08
- DOI
- https://doi.org/10.22603/ssrr.2024-0147
- Citations
- 1
- Primary Topic
- Hemostasis and retained surgical items
- Type
- article
- Field-Weighted Citation Impact
- 0.45
Funders
- Astellas Pharma
- Astellas Foundation for Research on Metabolic Disorders