NLRP3 Inflammasome Inhibition After Pilocarpine-Induced Status Epilepticus Attenuates Chronic Inflammation in Epileptic Mice
Inhibition of NLRP3 inflammasome post-SE effectively ameliorates neuronal loss, seizure susceptibility, and cognitive dysfunction during epileptogenesis. This neuroprotective effect may be mediated through the mitigation of chronic pro-inflammatory responses within the epileptic brain.
Authors
- Zhong Dong
- Xiaoyu Zhang (ORCID: https://orcid.org/0009-0007-9803-2885)
- Yu‐Wen Chen (ORCID: https://orcid.org/0000-0002-2934-7767)
- Yu Wang (ORCID: https://orcid.org/0000-0002-4153-7360)
- Wenhao Xu (ORCID: https://orcid.org/0000-0001-7164-4418)
- Lei Wang (ORCID: https://orcid.org/0000-0002-4705-0908)
- Kai Wang (ORCID: https://orcid.org/0000-0002-2312-8109)
Institutions
- Anhui Medical University (CN)
- Anqing City Hospital (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Third People's Hospital of Hefei (CN)
- Anhui Mental Health Center (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2024-09-01
- DOI
- https://doi.org/10.2147/jir.s469451
- Citations
- 6
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.40