Chrysin-Loaded Snedds: A Novel Approach To Boost Bioavailability Performance

Chrysin, a natural flavonoid found in propolis, honey, and some plants, has potential uses in medicine because to its anti-inflammatory, neuroprotective, antioxidant, anti-cancer, and anxiolytic characteristics. However, its poor solubility and bioavailability pose issues that necessitate effective delivery strategies. Drug delivery systems (DDS) including liposomes, transdermal patches, and nanoparticles may boost bioavailability and limit unwanted effects. SNEDDS, a mixture of oils, surfactants, and co-surfactants, form nano-sized emulsions in the gastrointestinal system to increase medicine absorption. This research investigates the development of SNEDDS for chrysin, concentrating on formulation optimization, in vitro drug release assessment, and solubility augmentation. The best excipients were identified using pseudo-ternary phase diagrams, Tween 80, and PEG 400, and solubility tests were undertaken. Four formulations (F1–F4) were produced and tested using a 22-factorial design. Zeta potential studies proved the stability of the nanoemulsions, and Fourier Transform Infrared (FT-IR) analysis indicated no chemical interaction between the excipients and the chrysin. The revised chrysin SNEDDS formulation, F4, displayed better drug release, bioavailability, and stability, making it a feasible choice for future investigation and improvement in oral drug delivery systems. SNEDDS offer a realistic technique for overcoming chrysin's solubility and bioavailability difficulties, with F4 formulation showing the greatest potential for medicinal application.