Intratumoral CXCL13<sup>+</sup> CD160<sup>+</sup> CD8<sup>+</sup> T cells promote the formation of tertiary lymphoid structures to enhance the efficacy of immunotherapy in advanced gastric cancer
The number and maturity of TLSs, along with the extent of CXCL13<sup>+</sup> CD160<sup>+</sup> CD8<sup>+</sup> T-cell infiltration, might function as potential indicators for assessing the effectiveness of immunotherapy in treating gastric malignancies. Furthermore, our research suggests that vitamin B<sub>6</sub> could enhance the secretion of CXCL13 by CD160<sup>+</sup> CD8<sup>+</sup> T cells by reducing the degradation of HIF-1α. Additionally, we demonstrate that vitamin B<sub>6</sub> supplementation or targeting pyridoxal kinase could substantially improve the efficacy of immunotherapies for gastric cancer.
Authors
- Shuqing Cao
- Zekuan Xu
- Ao X (ORCID: https://orcid.org/0000-0002-6522-5687)
- Pengyu Li (ORCID: https://orcid.org/0000-0003-3898-1898)
- Xinyu Zhao (ORCID: https://orcid.org/0000-0002-5128-4424)
- Li Yang (ORCID: https://orcid.org/0000-0001-5456-1944)
- Yuan Li (ORCID: https://orcid.org/0000-0003-3935-7237)
- Jian Xiao (ORCID: https://orcid.org/0000-0002-6591-3324)
- Yuan Liang (ORCID: https://orcid.org/0009-0000-5758-4906)
- Jiawei Wang
- Jiacheng Dong
Institutions
- Jiangsu Province Hospital (CN)
- Southeast University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1136/jitc-2024-009603
- Citations
- 17
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 4.80
Funders
- National Natural Science Foundation of China