MHC class I and II-deficient humanized mice are suitable tools to test the long-term antitumor efficacy of immune checkpoint inhibitors and T-cell engagers
Humanized MHC-dKO immunodeficient mice allow and refine the preclinical testing of immunotherapy agents for which experimentation is precluded in conventional immunodeficient mice due to severe xGVHD.
Authors
- Doina Cuculescu
- Rafael Salido‐Vallejo (ORCID: https://orcid.org/0000-0001-7210-8959)
- Gracián Camps (ORCID: https://orcid.org/0000-0002-8830-9517)
- Marı́a G. Campos (ORCID: https://orcid.org/0000-0001-7154-8717)
- Miguel F. Sanmamed (ORCID: https://orcid.org/0000-0002-7295-6074)
- Ignacio Melero (ORCID: https://orcid.org/0000-0002-1360-348X)
- Inmaculada Rodríguez López
- Carlos E. de Andrea (ORCID: https://orcid.org/0000-0002-7628-8050)
- Laura Álvarez-Gigli (ORCID: https://orcid.org/0000-0002-7680-3569)
- Pedro Berraondo (ORCID: https://orcid.org/0000-0001-7410-1865)
- Raluca Alexandru (ORCID: https://orcid.org/0009-0002-1903-5636)
- Iñaki Eguren‐Santamaría (ORCID: https://orcid.org/0000-0003-1581-3728)
- Eva Fernández de Piérola
- Inmaculada Aguilera-Buenosvinos (ORCID: https://orcid.org/0000-0003-2969-5347)
- Paula Martín-Muñoz
Institutions
- Navarre Institute of Health Research (ES)
- Clinica Universidad de Navarra (ES)
- CIC energiGUNE (ES)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
- Universidad de Navarra (ES)
- Chartered Institute of Management Accountants (GB)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1136/jitc-2023-008516
- Citations
- 8
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 2.26
Funders
- Bristol-Myers Squibb
- AstraZeneca
- Ministerio de Ciencia, Innovación y Universidades
- Mark Foundation For Cancer Research
- Fundación Científica Asociación Española Contra el Cáncer
- Ministerio de Ciencia e Innovación
- Fundación Fero
- CRIS Cancer Foundation
- Instituto de Salud Carlos III
- European Regional Development Fund
- Agencia Estatal de Investigación