Angiotensin receptor blocker attacks armored and cold tumors and boosts immune checkpoint blockade
Overall, we identify AGTR1 as a novel target in armored and cold tumors and demonstrate the improved therapeutic efficacy of ICB in combination with ARB. These findings could provide novel clinical insight into how to treat patients with refractory armored and cold tumors.
Authors
- Jie Mei (ORCID: https://orcid.org/0000-0001-7799-8129)
- Yun Cai (ORCID: https://orcid.org/0000-0002-5402-8143)
- Yichao Zhu (ORCID: https://orcid.org/0000-0003-3499-8510)
- Junying Xu (ORCID: https://orcid.org/0000-0001-6400-0606)
- Zhiwen Luo (ORCID: https://orcid.org/0000-0002-0524-9951)
- Jiayue Yang (ORCID: https://orcid.org/0000-0001-8463-0883)
- Kai Yang (ORCID: https://orcid.org/0000-0002-1982-4398)
- Yongmei Yin (ORCID: https://orcid.org/0000-0003-3335-369X)
- Qing Li (ORCID: https://orcid.org/0000-0003-2652-6070)
- Qinglin Zhang (ORCID: https://orcid.org/0000-0002-3640-2883)
- Yan Zhang (ORCID: https://orcid.org/0000-0002-7983-8396)
- Jiahui Chu (ORCID: https://orcid.org/0000-0003-2949-1491)
- Junli Ding
- Ning Xue (ORCID: https://orcid.org/0009-0009-0377-5868)
- Mengyun Wan
Institutions
- Jiangnan University (CN)
- Jiangsu University (CN)
- Xuzhou Medical College (CN)
- Fudan University (CN)
- Nanjing Maternity and Child Health Care Hospital (CN)
- Wuxi Fourth People's Hospital (CN)
- Jintan People's Hospital (CN)
- Xuzhou Central Hospital (CN)
- Jiangsu Province Hospital (CN)
- Wuxi People's Hospital (CN)
- Huashan Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1136/jitc-2024-009327
- Citations
- 22
- Primary Topic
- Cancer, Stress, Anesthesia, and Immune Response
- Type
- article
- Field-Weighted Citation Impact
- 8.48
Funders
- National Natural Science Foundation of China