Exploring shared mechanisms between ulcerative colitis and psoriasis and predicting therapeutic natural compounds through bioinformatics and molecular docking
MMP9, MMP1, and CXCL10, central mediators in the inflammatory pathways of UC and PS, establish a shared mechanism by triggering cytokine and chemokine activation, leading to tissue damage and positioning them as promising therapeutic targets for both conditions. Compounds such as quercetin, luteolin, irisolidone, rutaecarpine, and so on may be key drugs for treating both conditions. These findings suggest the potential advancement of therapeutic strategies and the enhancement of patient care by exploring shared mechanisms and predicting promising natural compounds for treating UC and PS.
Authors
- Shengwei Hong (ORCID: https://orcid.org/0000-0002-6851-867X)
- Wenjun Mao (ORCID: https://orcid.org/0000-0002-4644-9749)
- Zijian Guo (ORCID: https://orcid.org/0000-0002-2888-7016)
- Zhu Fan (ORCID: https://orcid.org/0000-0002-7535-2823)
- Bingnan Cui (ORCID: https://orcid.org/0000-0002-8790-1383)
- Jiao Yang (ORCID: https://orcid.org/0000-0002-1553-5425)
- Yixuan Yang
- Ying Cai (ORCID: https://orcid.org/0000-0003-4105-5916)
- Zhuozhi Gong
- Mengting Qiu
Institutions
- Nanjing University of Chinese Medicine (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Wangjing Hospital of China Academy of Chinese Medical Sciences (CN)
- Guang’anmen Hospital (CN)
Publication Details
- Journal
- Heliyon
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e37624
- Citations
- 5
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 1.20
Funders
- China Academy of Chinese Medical Sciences
- Beijing Municipal Science and Technology Commission