GluN2B on Adult-Born Granule Cells Modulates (<i>R,S</i>)-Ketamine’s Rapid-Acting Effects in Mice
In line with previous studies, these results suggest that 6-week-old adult-born hippocampal neurons expressing GluN2B partially modulate (R,S)-ketamine's rapid-acting effects. Future work targeting these 6-week-old adult-born neurons may prove beneficial for increasing the efficacy of (R,S)-ketamine.
Authors
- Sean C. Lim (ORCID: https://orcid.org/0000-0002-6406-7074)
- Ezra Sydnor (ORCID: https://orcid.org/0009-0000-3691-1103)
- Christina T. LaGamma (ORCID: https://orcid.org/0009-0001-7728-4182)
- Nicholas E. Bulthuis (ORCID: https://orcid.org/0000-0002-2367-7992)
- Christine A. Denny (ORCID: https://orcid.org/0000-0002-6926-2020)
- Claire Shubeck (ORCID: https://orcid.org/0009-0000-3019-7068)
- Josephine C. McGowan (ORCID: https://orcid.org/0000-0001-5132-3377)
- Rebecca A. Brachman (ORCID: https://orcid.org/0000-0002-1221-0414)
- Michael R. Drew (ORCID: https://orcid.org/0000-0002-3883-1542)
- Dong-oh Seo (ORCID: https://orcid.org/0000-0003-0315-4489)
- Ina P. Pavlova
- Liliana R Ladner (ORCID: https://orcid.org/0000-0003-3841-5087)
Institutions
- Columbia University Irving Medical Center (US)
- Research Foundation For Mental Hygiene (US)
- New York State Psychiatric Institute
- Columbia University (US)
- The University of Texas at Austin (US)
- Barnard College (US)
Publication Details
- Journal
- The International Journal of Neuropsychopharmacology
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1093/ijnp/pyae036
- Citations
- 2
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.54
Funders
- National Science Foundation
- Brain and Behavior Research Foundation
- New York State Psychiatric Institute
- National Institutes of Health
- National Institute of Mental Health
- National Institute of Neurological Disorders and Stroke
- National Institute of Child Health and Human Development