Synergistic Effect of Ubiquitin-Specific Protease 14 and Poly(ADP-Ribose) Glycohydrolase Co-Inhibition in BRCA1-Mutant, Poly(ADP-Ribose) Polymerase Inhibitor-Resistant Triple-Negative Breast Cancer Cells
USP14 inhibition may be a plausible strategy for expanding the utility of PARG inhibitors in TNBC in BRCA-mutant, PARP inhibitor-resistant settings.
Authors
- Wei Yuan (ORCID: https://orcid.org/0000-0001-5694-8835)
- Xiaoyu Zhu (ORCID: https://orcid.org/0000-0003-1882-9530)
- Hui Qu (ORCID: https://orcid.org/0000-0003-4809-570X)
- Xingyu Yao
- Hongshen Chen (ORCID: https://orcid.org/0009-0009-5334-4492)
- Pisong Li
- Baijun Li (ORCID: https://orcid.org/0000-0003-1214-9913)
- Zhongbin Han
Institutions
- Affiliated Zhongshan Hospital of Dalian University (CN)
Publication Details
- Journal
- OncoTargets and Therapy
- Published
- 2024-09-01
- DOI
- https://doi.org/10.2147/ott.s463217
- Citations
- 3
- Primary Topic
- PARP inhibition in cancer therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.85