Immune isolation-enabled nanoencapsulation of donor T cells: a promising strategy for mitigating GVHD and treating AML in preclinical models
Encapsulated donor T cells effectively mitigate GVHD while preserving the GVL effect by minimizing co-stimulatory signaling with APCs through early immune isolation. Subsequent degradation of nanocapsules restores T-cell cytotoxic efficacy against AML cells, mediated by cytotoxic pathways. Using transplant-encapsulated T cells offers a promising strategy to suppress GVHD while preserving the GVL effect.
Authors
- Yuchen Zhao (ORCID: https://orcid.org/0009-0002-6371-1822)
- Jinru Ge
- Lingling Zhang (ORCID: https://orcid.org/0000-0001-5070-8523)
- Li Xu (ORCID: https://orcid.org/0000-0001-6883-6590)
- Xian‐Zheng Zhang (ORCID: https://orcid.org/0000-0001-6242-6005)
- Ziyang Xue (ORCID: https://orcid.org/0000-0001-7887-7249)
- Yi‐Ning Yang (ORCID: https://orcid.org/0000-0002-8332-8508)
- Yuanfang Zhai
- Dan Mei (ORCID: https://orcid.org/0000-0002-1008-2789)
- Hongxia Li (ORCID: https://orcid.org/0000-0003-4981-4489)
- Ziwei Zhang (ORCID: https://orcid.org/0000-0002-5705-4611)
- Han Wang (ORCID: https://orcid.org/0000-0002-1442-4539)
- Zhimin Zhai (ORCID: https://orcid.org/0000-0003-4060-7600)
- Qianqian Yu
- Qianshan Tao (ORCID: https://orcid.org/0000-0003-1269-5850)
- Tianjing Zhang (ORCID: https://orcid.org/0000-0002-7809-6845)
- Jian Hong (ORCID: https://orcid.org/0000-0003-2502-6525)
- Lin Jin
- Qingsheng Li
Institutions
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
- Third People's Hospital of Hefei (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1136/jitc-2023-008663
- Citations
- 5
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 1.20
Funders
- National Natural Science Foundation of China