One‐Pot Synthesis of 2,4,6‐Trialkoxy‐ and Triaryloxybenzoates by Cs<sub>2</sub>CO<sub>3</sub>‐Mediated Tandem Dimerization/(3+3) Cyclocondensation of 1,3‐Acetonedicarboxylates
Abstract In this study, Cs 2 CO 3 ‐mediated one‐pot tandem dimerization/(3+3) cyclocondensation of 1,3‐acetonedicarboxylates followed by substitution of alkyl or aryl halides was developed to construct functionalized 2,4,6‐trialkoxy‐ and triaryloxybenzoates. In the effective reaction, the core benzene system was formed in a single‐step process under open‐vessel conditions. A plausible mechanism for this reaction is proposed and discussed herein.
Authors
- Meng‐Yang Chang (ORCID: https://orcid.org/0000-0002-1983-8570)
- Chin-Huey Ho
Institutions
- Kaohsiung Medical University (TW)
- National Pingtung University of Science and Technology (TW)
- Kaohsiung Medical University Chung-Ho Memorial Hospital (TW)
Publication Details
- Journal
- Advanced Synthesis & Catalysis
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1002/adsc.202400942
- Primary Topic
- Multicomponent Synthesis of Heterocycles
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science and Technology Council