Multicenter, multivendor validation of liver quantitative susceptibility mapping in patients with iron overload at 1.5 T and 3 T
QSM as an imaging biomarker of liver iron overload is feasible and repeatable across centers and MR vendors. It may be complementary with <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:semantics> <mml:mrow><mml:msubsup><mml:mi>R</mml:mi> <mml:mn>2</mml:mn> <mml:mo>*</mml:mo></mml:msubsup> </mml:mrow> <mml:annotation>$$ {\mathrm{R}}_2^{\ast } $$</mml:annotation></mml:semantics> </mml:math> as they are obtained from the same acquisition. Although good reproducibility was observed, liver QSM may benefit from standardization of acquisition parameters. Overall, QSM is a promising method for liver iron quantification.
Authors
- Ryan J. Mattison (ORCID: https://orcid.org/0000-0001-8574-8365)
- Collin J. Buelo (ORCID: https://orcid.org/0000-0003-4831-7333)
- Qing Yuan (ORCID: https://orcid.org/0000-0001-9851-0284)
- Dimitrios C. Karampinos (ORCID: https://orcid.org/0000-0003-4922-3662)
- Mounes Aliyari Ghasabeh (ORCID: https://orcid.org/0000-0001-7253-9310)
- Julia Velikina (ORCID: https://orcid.org/0000-0002-2058-8601)
- Lu Mao (ORCID: https://orcid.org/0000-0002-8626-9822)
- Iván Pedrosa (ORCID: https://orcid.org/0000-0002-0371-8689)
- Diego Hernando (ORCID: https://orcid.org/0000-0002-0016-0317)
- Michael Jeng (ORCID: https://orcid.org/0000-0001-8200-8484)
- Scott B. Reeder (ORCID: https://orcid.org/0000-0003-4728-8171)
- Ihab R. Kamel (ORCID: https://orcid.org/0000-0003-0511-7796)
- Ruiyang Zhao (ORCID: https://orcid.org/0000-0002-2386-9767)
- Shreyas Vasanawala (ORCID: https://orcid.org/0000-0002-1999-6595)
- Takeshi Yokoo (ORCID: https://orcid.org/0000-0002-5092-6931)
- David Harris (ORCID: https://orcid.org/0000-0002-1150-8702)
- Stefan Ruschke (ORCID: https://orcid.org/0000-0001-9658-6541)
Institutions
- University of Wisconsin–Madison (US)
- TUM Klinikum (DE)
- Advanced Imaging Research (United States) (US)
- Technical University of Munich (DE)
- The University of Texas Southwestern Medical Center (US)
- Stanford University (US)
Publication Details
- Journal
- Magnetic Resonance in Medicine
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1002/mrm.30251
- Citations
- 1
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.44
Funders
- National Institutes of Health