Chrysophanol-mediated trx-1 activation attenuates renal fibrosis through inhibition of the JNK/Cx43 signaling pathway
This study demonstrated a significant inhibitory effect of chrysophanol on renal fibrosis, mediated by the activation of Trx-1 to inhibit the JNK/Cx43 pathway. These findings provide experimental support for the potential use of chrysophanol as a therapeutic agent for renal fibrosis.
Authors
- Mingjia Gu (ORCID: https://orcid.org/0000-0001-9677-8279)
- Neng Bao (ORCID: https://orcid.org/0000-0002-6841-1311)
- Fang Cao (ORCID: https://orcid.org/0000-0002-4900-8957)
- Qiyu Yue
- Wei Kong
- Xuejing Gu (ORCID: https://orcid.org/0009-0001-8370-5457)
- Kejian Wen
- Jin Wang (ORCID: https://orcid.org/0009-0002-4560-8231)
Institutions
- Jiangnan University (CN)
- Nanjing University of Chinese Medicine (CN)
- Wuxi Fourth People's Hospital (CN)
Publication Details
- Journal
- Renal Failure
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1080/0886022x.2024.2398710
- Citations
- 5
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.20
Funders
- Government of Jiangsu Province
- Nanjing University