Betulin ameliorates neuronal apoptosis and oxidative injury via <scp>DJ</scp>‐1/Akt/Nrf2 signaling pathway after subarachnoid hemorrhage
Betulin which was a potent agonist of DJ-1 had the ability to induce its expression in brain tissue. DJ-1 had neuroprotective effect on EBI through comprehensive mechanisms, including facilitating intrinsic and extrinsic antiapoptotic pathway, and reducing oxidative injury by upregulating the expression of redox proteins. Betulin as an inexpensive drug showed the potential for SAH treatment.
Authors
- Yuansheng Zhang (ORCID: https://orcid.org/0000-0001-6876-4611)
- Qixiong Lu
- Tao Li (ORCID: https://orcid.org/0000-0003-0792-003X)
- Wei Huang (ORCID: https://orcid.org/0000-0003-0709-7741)
- Xiaoyang Lu
- Zaihong Cha
- Shu Yang
Institutions
- Kunming University of Science and Technology (CN)
- First People's Hospital of Yunnan Province (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1111/cns.70019
- Citations
- 6
- Primary Topic
- ATP Synthase and ATPases Research
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- National Natural Science Foundation of China
- Kunming Medical University
- Kunming University of Science and Technology
- Yunnan Provincial Science and Technology Department
- China International Medical Foundation