Suppressing upregulation of fibrinogen after polytrauma mitigates thrombosis in mice
The rise of fibrinogen and the size of thrombi after polytrauma can be mitigated via the administration of siRNA against fibrinogen. siFibrinogen represents a promising novel target for VTE prophylaxis posttrauma.
Authors
- Matthew J. Flick (ORCID: https://orcid.org/0000-0002-5034-3162)
- Christian J. Kastrup (ORCID: https://orcid.org/0000-0003-3644-0019)
- Francesca Ferraresso
- Mitchell Dyer
- William G Hayssen
- Monica S Seadler
- Marc de Moya
- Amber Haugen
- Muskan Bansal
Institutions
- Versiti Blood Center of Wisconsin (US)
Publication Details
- Journal
- The Journal of Trauma: Injury, Infection, and Critical Care
- Published
- 2024-09-06
- DOI
- https://doi.org/10.1097/ta.0000000000004442
- Citations
- 2
- Primary Topic
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 0.84