Diagnostic performance of metagenomic sequencing in patients with suspected infection: a large-scale retrospective study
Through this large-scale study, we further illustrated that mNGS had a clinically accepted rate and sensitivity superior to those of the traditional culture method in diagnosing infections. Moreover, blood and paired RT samples mostly shared partial-matched positive pathogens, especially for pathogens with abundant read numbers in RT, indicating that both blood and RT mNGS can aid the identification of pathogens for respiratory system infection.
Authors
- Zhiyang Chen (ORCID: https://orcid.org/0000-0002-0147-3489)
- Qichen Long (ORCID: https://orcid.org/0000-0001-7545-7230)
- Min Hu (ORCID: https://orcid.org/0000-0002-7018-3872)
- Tan Li (ORCID: https://orcid.org/0000-0003-4135-4879)
- Bin Yang (ORCID: https://orcid.org/0000-0003-0425-2718)
- Zhe Guo
- Zhongyuan Xiang
- Ziyang Li (ORCID: https://orcid.org/0009-0008-1724-207X)
- Bingxue Hu (ORCID: https://orcid.org/0000-0001-9116-6249)
- Weimin Wu (ORCID: https://orcid.org/0009-0004-5901-0219)
- Huifang Liu (ORCID: https://orcid.org/0009-0002-3982-355X)
- Jialiang Zhang (ORCID: https://orcid.org/0000-0002-0340-8971)
Institutions
- Central South University (CN)
- Vision Medicals (China) (CN)
- Second Xiangya Hospital of Central South University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2024-09-06
- DOI
- https://doi.org/10.3389/fcimb.2024.1463081
- Citations
- 5
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 1.93
Funders
- National Natural Science Foundation of China
- Central South University
- Xiangya Hospital, Central South University