Serotonergic transmission plays differentiated roles in the rapid and sustained antidepressant‐like effects of ketamine
This study confirms the requirement of serotonergic neurotransmission for the sustained antidepressant-like effects of ketamine, which appears to involve AMPA receptors, and provides avenues to search for antidepressant pharmacological targets.
Authors
- Yu‐Qiang Ding (ORCID: https://orcid.org/0000-0003-1202-4635)
- Jiao‐Zhao Yan (ORCID: https://orcid.org/0000-0001-7078-7871)
- Yunfeng Li (ORCID: https://orcid.org/0000-0002-5415-7420)
- Liming Zhang (ORCID: https://orcid.org/0000-0002-9071-8985)
- Yong‐Yu Yin (ORCID: https://orcid.org/0000-0003-3045-5543)
- Qianqian Wei (ORCID: https://orcid.org/0000-0002-3754-9246)
- Si‐Rui Sun (ORCID: https://orcid.org/0009-0006-4472-1776)
Institutions
- Beijing Institute of Education (CN)
- Capital Medical University (CN)
- Nantong University (CN)
- Fudan University (CN)
- Beijing Ditan Hospital (CN)
- Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1111/bph.17324
- Citations
- 11
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 4.93
Funders
- National Natural Science Foundation of China