Multi‐omics Analysis to Identify Key Immune Genes for Osteoporosis based on Machine Learning and Single‐cell Analysis
Neutrophils play a crucial role in the occurrence and development of osteoporosis. The four hub genes potentially inhibit metabolic activities and trigger inflammation by interacting with other immune cells, thereby significantly contributing to the onset and diagnosis of OP.
Authors
- Jirigala Ariben
- Chenyang Meng
- Baoxin Zhang (ORCID: https://orcid.org/0000-0002-5952-5376)
- Lina Wu (ORCID: https://orcid.org/0000-0002-3220-6041)
- Siqin Li (ORCID: https://orcid.org/0009-0003-0161-8689)
- Wanxiong He
- Zhenqun Zhao (ORCID: https://orcid.org/0000-0003-3839-8344)
- Zhiwei Pei (ORCID: https://orcid.org/0000-0001-9569-7485)
- Xiaolong Yang (ORCID: https://orcid.org/0000-0002-1475-3279)
- Xing Wang (ORCID: https://orcid.org/0000-0001-9930-3287)
- Xinlong Ma
- Lina Wu
- Ting Hao (ORCID: https://orcid.org/0009-0006-8671-4726)
- Fei Xue (ORCID: https://orcid.org/0000-0002-0944-8501)
- Feng Zheng (ORCID: https://orcid.org/0009-0001-7190-5814)
- Aixian Tian
- Chao Sun
Institutions
- Tianjin University (CN)
- Soochow University (CN)
- Second Affiliated Hospital of Inner Mongolia Medical University (CN)
- Tianjin People's Hospital (CN)
- Sanya Central Hospital (CN)
- Tianjin Hospital (CN)
- Tianjin Medical University Eye Hospital (CN)
- Qinghai Provincial Peoples Hospital (CN)
- Inner Mongolia Medical University (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Orthopaedic Surgery
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1111/os.14172
- Citations
- 7
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.64
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China