MASLD in people with HIV exhibits higher fibrosis stage despite lower disease activity than in matched controls
The NAS and histological drivers of fibrosis (e.g. inflammation and hepatocyte ballooning) are less pronounced in MASLD-PWH, and yet fibrosis stage was generally higher when compared to matched controls with MASLD without HIV. This suggests HIV-specific factors beyond hepatic necroinflammation may contribute to fibrosis progression in MASLD-PWH.
Authors
- Daniela Allende (ORCID: https://orcid.org/0000-0001-9868-8269)
- Oscar W. Cummings (ORCID: https://orcid.org/0000-0003-4639-1660)
- Patricia Belt
- David E. Kleiner (ORCID: https://orcid.org/0000-0003-3442-4453)
- Samer Gawrieh (ORCID: https://orcid.org/0000-0002-2056-4909)
- Ryan M. Gill (ORCID: https://orcid.org/0000-0001-6229-7928)
- Colleen Hadigan (ORCID: https://orcid.org/0000-0003-0642-7817)
- Susanna Naggie (ORCID: https://orcid.org/0000-0001-7721-6975)
- Rohit Seth Loomba (ORCID: https://orcid.org/0000-0002-4845-9991)
- Jennifer C. Price (ORCID: https://orcid.org/0000-0002-3825-5696)
- Cynthia A. Behling (ORCID: https://orcid.org/0000-0001-7016-2636)
- Laura Wilson (ORCID: https://orcid.org/0000-0002-6294-4504)
- Cynthia D. Guy (ORCID: https://orcid.org/0000-0002-4959-751X)
- Holly Crandall
- Matthew M. Yeh (ORCID: https://orcid.org/0000-0002-3004-8799)
- Naga Chalasani (ORCID: https://orcid.org/0000-0003-4082-3178)
- Danielle Carpenter (ORCID: https://orcid.org/0000-0001-7203-7046)
- Richard K. Sterling (ORCID: https://orcid.org/0000-0002-8637-2475)
- Mary McLaughlin
Institutions
- Cleveland Clinic (US)
- Johns Hopkins University (US)
- Duke University (US)
- University of California, San Francisco (US)
- Virginia Commonwealth University (US)
- University of Washington (US)
- University Health System (US)
- University of California San Diego (US)
- Clinical Research Institute (US)
- Pacific Rim Engineering (United States) (US)
- National Institute of Allergy and Infectious Diseases (US)
- National Cancer Institute (US)
- Indiana University School of Medicine
- Saint Louis University (US)
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alimentary Pharmacology & Therapeutics
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1111/apt.18236
- Citations
- 14
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.41
Funders
- Pfizer
- Ipsen
- National Institutes of Health
- National Cancer Institute
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Center for Advancing Translational Sciences