<i>gem</i>-Difluorination of carbon–carbon triple bonds using Brønsted acid/Bu<sub>4</sub>NBF<sub>4</sub> or electrogenerated acid
<i>gem</i>-Difluorination of carbon-carbon triple bonds was conducted using Brønsted acids, such as Tf<sub>2</sub>NH and TfOH, combined with Bu<sub>4</sub>NBF<sub>4</sub> as the fluorine source. The electrochemical oxidation of a Bu<sub>4</sub>NBF<sub>4</sub>/CH<sub>2</sub>Cl<sub>2</sub> solution containing alkyne substrates could also give the corresponding <i>gem</i>-difluorinated compounds (<i>in-cell</i> method). The <i>ex-cell</i> electrolysis method was also applicable for <i>gem</i>-difluorination of alkynes.
Authors
- Hiroki Shimao
- Keiji Nishiwaki (ORCID: https://orcid.org/0000-0001-5017-244X)
- Kengo Hamasaki
- Kouichi Matsumoto (ORCID: https://orcid.org/0000-0003-2592-7403)
- Mizuki Yamaguchi
- Shigenori Kashimura
Institutions
- Kindai University (JP)
Publication Details
- Journal
- Beilstein Journal of Organic Chemistry
- Published
- 2024-09-06
- DOI
- https://doi.org/10.3762/bjoc.20.194
- Citations
- 5
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 1.04
Funders
- Kindai University
- Kanazawa University
- Japan Society for the Promotion of Science