Iodine-Mediated One-Pot Synthesis of Imidazo[1,5-a]Pyridines

In this report, we developed an efficient one-pot method for the synthesis of 3-phenyl-1-(phenylthio)imidazo[1,5-a]pyridine analogs starting from 2-aminomethylpyridines, benzaldehydes, and sodium benzenesulfinates, which constructed C-N and C-S bonds simultaneously. The method features mild reaction conditions, a wide range of substrates, high atom utilization, and convenient and easily accessible starting materials.

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Publication Details

Journal
Catalysts
Published
2024-09-06
DOI
https://doi.org/10.3390/catal14090601
Citations
1
Primary Topic
Catalytic C–H Functionalization Methods
Type
article
Field-Weighted Citation Impact
0.25

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article

Iodine-Mediated One-Pot Synthesis of Imidazo[1,5-a]Pyridines

Lang Huang, Yarong Liu, Zhi‐Bing Dong, Zhipeng Guan
1 citations
Catalysts
Catalytic C–H Functionalization Methods
0.25
article

Iodine-Mediated One-Pot Synthesis of Imidazo[1,5-a]Pyridines

Lang Huang, Yarong Liu, Zhi‐Bing Dong, Zhipeng Guan
article en
1 citations

Abstract

In this report, we developed an efficient one-pot method for the synthesis of 3-phenyl-1-(phenylthio)imidazo[1,5-a]pyridine analogs starting from 2-aminomethylpyridines, benzaldehydes, and sodium benzenesulfinates, which constructed C-N and C-S bonds simultaneously. The method features mild reaction conditions, a wide range of substrates, high atom utilization, and convenient and easily accessible starting materials.

CatalystsVol. 14(9)
China Three Gorges University (CN), Henan Normal University (CN), Wuhan Institute of Technology (CN)
Natural Science Foundation of Hubei Province, Wuhan Institute of Technology
Openalex Percentile: Top 49%
Catalytic C–H Functionalization Methods
0.25
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