Does HLA explain the high incidence of childhood-onset type 1 diabetes in the Canary Islands? The role of Asp57 DQB1 molecules
In this population, the overall distributions of the HLA-DRB1 and HLA-DQB1 alleles are similar to those in other European populations. However, the frequency of the non-Asp-57 HLA-DQB1 molecules is greater than that in other populations with a lower incidence of T1D. Based on genetic, historical and epidemiological data, we propose that a common genetic background might help explain the elevated pediatric T1D incidence in the Canary Islands, North-Africa and middle eastern countries.
Authors
- Itahisa Marcelino-Rodríguez (ORCID: https://orcid.org/0000-0003-3645-3207)
- Santiago Sánchez‐Alonso
- Sara Guillén‐López (ORCID: https://orcid.org/0000-0001-6874-8662)
- Yeray Nóvoa Medina (ORCID: https://orcid.org/0000-0002-9564-0654)
- Nicolás M. Suárez (ORCID: https://orcid.org/0000-0001-8429-8374)
- Ángela Domı́nguez (ORCID: https://orcid.org/0000-0003-0219-1907)
- Carlos Flores (ORCID: https://orcid.org/0000-0001-5352-069X)
- Svetlana Pavlović (ORCID: https://orcid.org/0000-0001-7790-2692)
- Marta Barreiro-Bautista
- Sofía Quinteiro-González
- Gema González‐Martínez
- Eva Rivas-García
- M. Suárez Cabrera (ORCID: https://orcid.org/0000-0002-9077-8013)
Institutions
- Universidad de Las Palmas de Gran Canaria (ES)
- Universidad de La Laguna (ES)
- Hospital Universitario Insular de Gran Canaria (ES)
- Instituto de Salud Carlos III (ES)
- Universidad Fernando Pessoa Canarias (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (ES)
- Instituto Tecnológico y de Energías Renovables (ES)
- Gobierno de Canarias (ES)
- Fundación Canaria de Investigación Sanitaria (ES)
Publication Details
- Journal
- BMC Pediatrics
- Published
- 2024-09-06
- DOI
- https://doi.org/10.1186/s12887-024-04983-w
- Citations
- 2
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.10
Funders
- Fundación Mapfre