Metabolic Pathway of Osilodrostat in Equine Urine Established through High-resolution Mass Spectrometric Characterization for Doping Control
It is advisable to screen for both osilodrostat and its mono-hydroxylated metabolite M1c to effectively monitor horse urine for the potential misuse or abuse of osilodrostat. For suspicious samples, confirmation of osilodrostat using its reference material is required.
Authors
- Hirokazu Kunii
- Hideaki Ishii (ORCID: https://orcid.org/0000-0002-6850-1894)
- Gary N. W. Leung (ORCID: https://orcid.org/0000-0002-6949-5721)
- Takashi Yamanaka (ORCID: https://orcid.org/0000-0002-6259-0195)
- Daisuke Arima (ORCID: https://orcid.org/0000-0001-5920-2895)
- Reiko Yuasa
- Yuhiro Ishikawa (ORCID: https://orcid.org/0009-0008-7673-7961)
- Fumiaki Mizobe (ORCID: https://orcid.org/0000-0003-3998-1371)
- Motoi Nomura (ORCID: https://orcid.org/0000-0002-2778-9625)
- Masayuki Yamada (ORCID: https://orcid.org/0000-0001-6189-0367)
- Shun-ichi NAGATA (ORCID: https://orcid.org/0000-0001-9566-0498)
- Ryo Shigematsu (ORCID: https://orcid.org/0009-0000-4842-218X)
- Sohei Tanabe
- Shunsuke Takemoto
Institutions
- Tohoku University Hospital (JP)
- Laboratory of Racing Chemistry (JP)
- Japan Racing Association (JP)
Publication Details
- Journal
- Current Drug Metabolism
- Published
- 2024-09-06
- DOI
- https://doi.org/10.2174/0113892002325954240903062440
- Citations
- 1
- Primary Topic
- Muscle metabolism and nutrition
- Type
- article
- Field-Weighted Citation Impact
- 0.33