Effect of Antidepressants on Non-alcoholic Fatty Liver Disease and their Underlying Mechanism
Age, antidepressant type, duration of antidepressant use, and comorbidities could be risk factors for NAFLD in patients with depression. Furthermore, mirtazapine can cause steatosis in both AML-12 and MIHA cell lines and may promote the development of NAFLD through the TLR4/MyD88/NF-κB signaling pathway. This study lays a solid foundation for further research on depression and NAFLD and can contribute to the prevention and treatment of these two diseases.
Authors
- Yuyong Tan (ORCID: https://orcid.org/0000-0002-0571-3136)
- Yumin Qing (ORCID: https://orcid.org/0009-0002-2996-9774)
- Deliang Liu (ORCID: https://orcid.org/0000-0003-1541-2596)
- Jianglei Li (ORCID: https://orcid.org/0000-0002-5720-1087)
- Lini Liu (ORCID: https://orcid.org/0000-0002-1488-5722)
- Hailing Peng
- Fu S
- Liu Han
- Siyi Wang (ORCID: https://orcid.org/0009-0006-4909-2569)
Institutions
- Central South University (CN)
- Second People Hospital of Hunan (CN)
- Xian Yang Central Hospital (CN)
- Second Xiangya Hospital of Central South University (CN)
Publication Details
- Journal
- Current Medicinal Chemistry
- Published
- 2024-09-06
- DOI
- https://doi.org/10.2174/0109298673317281240828170031
- Citations
- 2
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.77