Specific Features of Juvenile Idiopathic Arthritis Patients’ Chemokine Profile: The Data of Case-Control Study Analysis
An increase in their content leads to active monocytes/macrophages migration to the site of inflammation, where they suppress effector T-cell activity by binding suppressor exosomes and activate B-cells by autoantigens presentation received due to joint tissue destruction. This allows us to speak about the predominance of the Th1-mediated immune response during the development of studied disease chronic inflammation.
Authors
- A. V. Rybakov (ORCID: https://orcid.org/0000-0001-8867-0161)
- D. I. Kozlova (ORCID: https://orcid.org/0000-0003-1767-2754)
- Vyacheslav I. Zorin (ORCID: https://orcid.org/0000-0002-9712-5509)
- Aleksei N. Kozhevnikov (ORCID: https://orcid.org/0000-0003-0509-6198)
- V. V. Khizha (ORCID: https://orcid.org/0000-0003-4967-472X)
- Mikhail Mikhaylovich Kostik (ORCID: https://orcid.org/0000-0002-1180-8086)
- Karina A. Yureva (ORCID: https://orcid.org/0000-0002-5225-3726)
- Lybov S. Sorokina
Institutions
- Russian Academy of Sciences (RU)
- Institute of Evolutionary Physiology and Biochemistry (RU)
- St Petersburg University (RU)
- Peter the Great St. Petersburg Polytechnic University (RU)
- Federal Almazov North-West Medical Research Centre (RU)
- The Turner Scientific Research Institute for Children's Orthopedics (RU)
- Saint Petersburg State Pediatric Medical University (RU)
Publication Details
- Journal
- Current Rheumatology Reviews
- Published
- 2024-09-06
- DOI
- https://doi.org/10.2174/0115733971308074240813060452
- Primary Topic
- Autoimmune and Inflammatory Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00