Lapatinib: A Potential Therapeutic Agent for Colon Cancer Targeting Ferroptosis
Our findings demonstrated that lapatinib could effectively suppress the mRNA and protein expression of GPX4 in colon cancer cells, which elevates intracellular levels of ROS and malondialdehyde, ultimately inducing ferroptosis in these cells. This mechanism underscores the potential of lapatinib as a therapeutic strategy for targeting tumors.
Authors
- Songbo Fu (ORCID: https://orcid.org/0000-0003-0611-6015)
- Xiujuan Lang (ORCID: https://orcid.org/0009-0007-1790-0266)
- Yuan Chen (ORCID: https://orcid.org/0000-0003-0228-4505)
- Yue Sun (ORCID: https://orcid.org/0009-0009-0481-5593)
- Dan Wang (ORCID: https://orcid.org/0000-0003-3209-1616)
Institutions
- Harbin Medical University (CN)
- Heilongjiang University of Chinese Medicine (CN)
- Heilongjiang University (CN)
Publication Details
- Journal
- Anti-Cancer Agents in Medicinal Chemistry
- Published
- 2024-09-06
- DOI
- https://doi.org/10.2174/0118715206327756240830062531
- Citations
- 7
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.00