In Silico Studies of Phytoconstituents to Identify Potential Inhibitors for ERα Protein of Breast Cancer
Among the top ten phytochemicals, ginicidin (glycoside) formed a more stable complex and had greater binding affinity than standard tamoxifen with better safety profiles. Hence, this compound can be further studied for lead optimization and drug development for the treatment of breast cancer.
Authors
- Aithamraju Satishchandra
- Mohaideen Thasthagir Sulthana (ORCID: https://orcid.org/0000-0002-7477-8144)
- V. Alagarsamy (ORCID: https://orcid.org/0000-0003-0165-7912)
- Sankaranarayanan Murugesan (ORCID: https://orcid.org/0000-0002-3680-1577)
- Viswas Raja Solomon (ORCID: https://orcid.org/0000-0002-9863-4452)
- Bandi Narendhar
- P. Parthiban
- Lalkote Aruna Jothi
Institutions
- MNR Medical College and Hospital (IN)
- Birla Institute of Technology and Science, Pilani (IN)
Publication Details
- Journal
- Medicinal Chemistry
- Published
- 2024-09-06
- DOI
- https://doi.org/10.2174/0115734064301748240821081206
- Citations
- 1
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.36