Effectiveness of Platelet-Rich Fibrin (PRF) in Enhancing Healing and Regeneration in Oral and Maxillofacial Surgery: A Quantitative Narrative Review

Background: Platelet-Rich Fibrin (PRF) is increasingly used in oral and maxillofacial surgery for its potential to enhance tissue healing and regeneration. PRF offers advantages due to its sustained release of growth factors and anti-inflammatory properties.Objective: This review aims to evaluate the effectiveness of PRF in bone regeneration, soft tissue healing, and reducing postoperative complications in oral and maxillofacial surgery.Methods: A quantitative narrative review was conducted using studies from PubMed, Cochrane CENTRAL, Embase, Web of Science, and Scopus, focusing on randomized controlled trials and clinical studies from 2010 to 2024. Data were synthesized from 155 studies involving 10,540 patients.Results: PRF significantly improved bone regeneration (SMD: 0.85), accelerated soft tissue healing (SMD: 0.74), and reduced postoperative complications (RR: 0.65). Leukocyte-rich PRF showed superior outcomes. Moderate heterogeneity was noted due to variations in PRF preparation protocols.Conclusion: PRF is effective in enhancing healing outcomes in oral and maxillofacial surgery. Standardizing preparation methods and exploring long-term effects could further optimize its clinical use.