(2 + 2 + 1)-Cyclization of Glycine Derivatives with Alkenes and CO<sub>2</sub>
A highly atom-economic (2 + 2 + 1)-cyclization of glycine derivatives with alkenes and CO<sub>2</sub> facilitated by visible light catalysis is described. A range of multisubstituted pyrrolidones were synthesized under simple and mild reaction conditions. A reasonable mechanism involving redox-neutral radical-polar crossover is proposed.
Authors
- Youwan Ye
- Congde Huo (ORCID: https://orcid.org/0000-0002-3374-7931)
Institutions
- Northwest Normal University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1021/acs.orglett.4c02805
- Citations
- 2
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.50
Funders
- National Natural Science Foundation of China