Gold-Catalyzed Alkyne Oxidative Cyclization/Mannich-Type Addition Cascade Reaction of Ynamides with 1,3,5-Triazinanes
Herein, a gold-catalyzed alkyne oxidative cyclization/Mannich-type addition cascade reaction of ynamides with 1,3,5-triazinanes in the presence of a Brønsted acid has been presented. A class of functionalized fluorenes bearing a quaternary carbon center was synthesized directly with moderate to excellent yields via in situ formed α-oxo carbenes using quinoline <i>N</i>-oxide as the oxidant under mild reaction conditions.
Authors
- Xinfang Xu (ORCID: https://orcid.org/0000-0002-8706-5151)
- Kemiao Hong
- Chao Li (ORCID: https://orcid.org/0000-0002-5864-5288)
- Jingjing Huang (ORCID: https://orcid.org/0000-0003-0522-9923)
- Ke-Wei Chen (ORCID: https://orcid.org/0009-0002-3579-240X)
- Shanliang Dong
Institutions
- Zhejiang Sci-Tech University (CN)
- Sun Yat-sen University (CN)
- Henan Normal University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-09-06
- DOI
- https://doi.org/10.1021/acs.joc.4c01784
- Citations
- 1
- Primary Topic
- Catalytic Alkyne Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.25
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province