FACTORS INFLUENCING INTRAUTERINE INSEMINATION OUTCOMES IN BRUNEI FEMALES

Objective: To determine the effects of female age, body mass index (BMI), hormonal profile, infertility duration, and causes on pregnancy outcomes of females undergoing intrauterine insemination (IUI). Material and Method: This retrospective study included 199 infertile females who underwent IUI from 2015 to 2019 at Raja-Is teri-Pengiran-Anak-Saleha Hospital, Brunei Darussalam. Age, BMI, hormonal profile, duration of infertility, and causes of infer tility associated with pregnancy outcome during treatment were studied. Urine pregnancy test confirmed the pregnancy post-IUI. The statistical analysis tests for categorical variables were the Chi-Square test and Fisher’s exact test. One-way ANOVA was used to assess numerical variables. P-values <0.05 were deemed statistically significant. Result: The mean age of the pregnant females was 32.8±4.9 years, the mean BMI was 24.7 kg/m2 and 12.5% of the participants had normal weight, 5.5% were overweight, and 9% were obese. Overall, 18 females (9%) achieved successful outcomes. Despite the lack of a significant relationship between BMI and pregnancy outcome, 83% of females with positive outcomes were obese. Furthermore, 72.2% of the females who were infertile for <6 years had conceived. A decreasing trend of hormones was noticed with an increasing BMI (p<0.05). Overall hormonal values did not significantly determine IUI outcome (p>0.05).Conclusion: Successful outcomes after IUI were observed in fe males with unexplained or female-caused infertility. Male infer tility did not influence the positive pregnancy outcome. Females with an age range of 30-39 years, duration of infertility less than six years, and BMI index of >25 kg/m2 were able to conceive.