Diabetes risk reduction diet and risk of liver cancer and chronic liver disease mortality: A prospective cohort study
After a median follow-up of 22.0 years, 216 incident liver cancer cases and 153 chronic liver disease deaths were confirmed. A higher DRRD score was significantly associated with a reduced risk of developing liver cancer (HR<sub>Tertile 3 vs. Tertile 1</sub> = 0.69; 95% CI: 0.49-0.97; P<sub>trend</sub> = 0.03) and chronic liver disease mortality (HR<sub>T3 vs. T1</sub> = 0.54; 95% CI: 0.35-0.82; P<sub>trend</sub> = 0.003). We further found inverse associations with dietary fiber and coffee, and positive associations with dietary glycemic index, SSBs, and trans fat. A higher DRRD score was associated with reduced risk of developing liver cancer and chronic liver disease mortality among postmenopausal women.
Authors
- Melissa Lopez‐Pentecost (ORCID: https://orcid.org/0000-0002-7048-3699)
- Longgang Zhao (ORCID: https://orcid.org/0000-0001-9254-1952)
- Su Yon Jung (ORCID: https://orcid.org/0000-0002-0513-1830)
- Jean Wactawski‐Wende (ORCID: https://orcid.org/0000-0003-3096-9595)
- Margaret S. Pichardo (ORCID: https://orcid.org/0000-0002-9132-4400)
- Nazmus Saquib (ORCID: https://orcid.org/0000-0002-2819-2839)
- Yangbo Sun (ORCID: https://orcid.org/0000-0003-0377-4450)
- Marian L. Neuhouser (ORCID: https://orcid.org/0000-0002-3876-0000)
- Fred K. Tabung (ORCID: https://orcid.org/0000-0001-8193-7150)
- Xuehong Zhang (ORCID: https://orcid.org/0000-0002-8260-8508)
- Yun Chen (ORCID: https://orcid.org/0009-0007-3876-2050)
- Tongzhang Zheng
- Thomas E. Rohan
- JoAnn E. Manson
Institutions
- Brigham and Women's Hospital (US)
- Albert Einstein College of Medicine (US)
- Harvard University (US)
- University of Miami (US)
- University of Tennessee Health Science Center (US)
- University of California, Los Angeles (US)
- Brown University (US)
- Hospital of the University of Pennsylvania (US)
- Sulaiman Al Rajhi Colleges (SA)
- Yale University (US)
- The Bronx Defenders (US)
- Fred Hutch Cancer Center (US)
- University of Pennsylvania Health System (US)
- Sylvester Comprehensive Cancer Center (US)
- The Ohio State University (US)
- University at Buffalo, State University of New York (US)
Publication Details
- Journal
- Journal of Internal Medicine
- Published
- 2024-09-06
- DOI
- https://doi.org/10.1111/joim.20007
- Citations
- 8
- Primary Topic
- Nutritional Studies and Diet
- Type
- article
- Field-Weighted Citation Impact
- 4.34
Funders
- U.S. Department of Health and Human Services
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Cancer Institute