Increased m6A RNA methylation and METTL3 expression may contribute to the synovitis progression of rheumatoid arthritis
Abnormal modification of m6A methylation exists in synovial tissues and FLSs of RA patients, and inhibition of METTL3 can reduce synovitis and bone destruction. Our findings suggest that m6A methylation might control FLS-mediated tumor-like phenotype, and be a novel target for RA treatment.
Authors
- Yang Liu (ORCID: https://orcid.org/0000-0002-2826-7407)
- Yazhen Su (ORCID: https://orcid.org/0000-0002-9512-5257)
- Zewen Wu (ORCID: https://orcid.org/0000-0001-9124-4577)
- Junqing Jia (ORCID: https://orcid.org/0009-0008-5123-3329)
- Xinling Liu (ORCID: https://orcid.org/0000-0003-3106-670X)
- Liyun Zhang (ORCID: https://orcid.org/0000-0002-0814-4872)
- Jie Kang (ORCID: https://orcid.org/0000-0002-4784-4951)
Institutions
- Shanxi Medical University (CN)
- Shanxi University (CN)
- Jinzhong University (CN)
- Shanxi Academy of Medical Sciences (CN)
Publication Details
- Journal
- Experimental Cell Research
- Published
- 2024-09-06
- DOI
- https://doi.org/10.1016/j.yexcr.2024.114237
- Citations
- 10
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.34
Funders
- Shanxi Medical University