Endothelial epoxyeicosatrienoic acid release is intact in aldosterone excess
EET release appears intact despite aldosterone excess. Epoxide hydrolase inhibition may revert aldosterone-induced functional changes in endothelial cells. These findings indicate a potential new therapeutic principle to address ED, which should be explored in future preclinical and clinical trials.
Authors
- Michael Mederos y Schnitzler
- Christian Adolf
- Felix Beuschlein (ORCID: https://orcid.org/0000-0001-7826-3984)
- Martín Reincke (ORCID: https://orcid.org/0000-0002-9817-9875)
- Holger Schneider (ORCID: https://orcid.org/0000-0003-1556-0951)
- Thomas Gudermann (ORCID: https://orcid.org/0000-0002-0323-7965)
- Fabien Riols
- Yao Meng (ORCID: https://orcid.org/0000-0001-5270-9714)
- Jair Marques (ORCID: https://orcid.org/0000-0002-8095-8475)
- Berthold V Koletzko (ORCID: https://orcid.org/0000-0002-5345-7165)
- Jeannie Horak (ORCID: https://orcid.org/0000-0002-0873-9358)
- Li Chen (ORCID: https://orcid.org/0000-0002-2152-6437)
- Jing Sun (ORCID: https://orcid.org/0000-0003-3642-051X)
- Daniel Heinrich (ORCID: https://orcid.org/0000-0002-7086-0562)
- Mark Haid
- Julien Kocabiyik
- Aynur Bilyal
Institutions
- Helmholtz Zentrum München (DE)
- LMU Klinikum (DE)
- Gansu Provincial Hospital (CN)
- German Centre for Cardiovascular Research (DE)
- Deutsches Herzzentrum München (DE)
- Universitätsklinik für Diabetologie, Endokrinologie, Ernährungsmedizin & Metabolismus (CH)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Atherosclerosis
- Published
- 2024-09-06
- DOI
- https://doi.org/10.1016/j.atherosclerosis.2024.118591
- Citations
- 2
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 0.72
Funders
- Deutsche Forschungsgemeinschaft
- Else Kröner-Fresenius-Stiftung
- Universität Zürich
- Horizon 2020 Framework Programme
- European Research Council
- Horizon 2020
- H2020 European Research Council